A Rare Presentation of a Malignant Melanoma Presenting as a Large Pulmonary Mass Causing Superior Vena Cava Obstruction

MICR-053
Joshua Wei Liang Yip, Han Loh, Veronica Chi Ken Wong, John J. Park, Tayyaba Khan and Chuong Bui
 
Abstract

 
A 50-year-old otherwise well man with a 20-pack year smoking history was referred for a computed tomography pulmonary angiogram (CTPA) to investigate progressive dyspnea and cough over several weeks. A large 16 cm solitary mass was discovered in the right hemithorax causing encasement of the superior vena cava (SVC) with an intraluminal obstructing SVC tumor thrombus. Initial CT did not reveal any further sites of distant metastatic disease for a presumed primary lung malignancy. However, a core biopsy revealed the mass to be the solitary presentation of a primary BRAF V600E positive malignant melanoma. Urgent initiation of molecular targeted therapy with combination tyrosine kinase inhibitors (dabrafenib (BRAF) / trametinib (MEK) inhibition) led to significant tumor regression, including of the extensive tumor thrombus.
 
Published on: August 05, 2020
doi: 10.17756/micr.2020-053
Citation: Yip JWL, Loh H, Wong VCK, Park JJ, Khan T, et al. 2020. A Rare Presentation of a Malignant Melanoma Presenting as a Large Pulmonary Mass Causing Superior Vena Cava Obstruction. J Med Imaging Case Rep 4(2): 59-62.

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