Abstract
Background: Transcatheter mitral valve edge-to-edge repair (M-TEER) in the setting of severe mitral regurgitation (MR) has experienced increased usage in recent years. To select appropriate candidates and plan for these procedures, the cardiologist must predict likely procedural outcomes dependent on factors such as clip type, size, and position. We have proposed a method to utilize computed tomography (CT) images to generate a patient specific procedural simulation model that allows these variables to be tested to support clinical decision making in patients undergoing M-TEER procedures.
Objectives: To compare the mitral valve simulation (MVS) prediction with the prediction generated by expert cardiologists to assess whether MVS is comparable to expert cardiologist in predicting residual MR post M-TEER.
Methods: The severity of residual MR post M-TEER device implant was predicted by MVS and by expert readers, using either pre-procedural transesophageal echocardiography (TEE) or CT imaging. The MVS and expert reader predictions were compared to a ground truth (GT). The accuracy between MVS and GT, and expert cardiologists and GT were calculated.
Results: We found that when comparing the error of predicted effective regurgitant orifice area (EROA) from MVS to GT, and expert readers to GT, the mean error is smaller between GT and MVS than between GT and expert readers. These results suggest that the accuracy of post-procedural EROA estimation by MVS is equivalent to the accuracy of expert cardiologists’ predictions.
Conclusion: The predicted reduction in MR related to clip placement generated by the MVS software demonstrates a strong correlation to GT and suggests that results are comparable to the predictions by expert readers. The findings of this study suggest that the MVS application can generate a prediction of the residual MR that is accurate, and consistent.
Published on: February 20, 2026
doi: 10.17756/micr.2026-123
Citation: Kofoed KF, Pham MHC, Chapman JV, Linde JJ, de Backer O, et al. 2026. Clinical Evaluation of a Mitral Valve Simulation Application Used to Support Planning of Transcatheter Edge to Edge Repair Procedures. J Med Imaging Case Rep 10(1): 1-8.
Downloads